Ontology highlight
ABSTRACT:
SUBMITTER: Ni J
PROVIDER: S-EPMC6585310 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ni Jingjing J Lin Miaotong M Jin Yangjie Y Li Jiajia J Guo Yayong Y Zhou Jindong J Hong Guangliang G Zhao Guangju G Lu Zhongqiu Z
Frontiers in pharmacology 20190613
Vascular endothelial functional dysregulation and barrier disruption are involved the initiation and development of sepsis. Growth arrest-specific protein 6 (Gas6), one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), is confirmed to have beneficial functions in hemostasis, inflammation, and cancer growth. Here, we demonstrated the protective effects of Gas6 on multi-organ dysfunction syndrome (MODS) in sepsis and the underlying mechanisms. We investigated Gas6-ameliorated MOD ...[more]