Ontology highlight
ABSTRACT:
SUBMITTER: Rosenqvist P
PROVIDER: S-EPMC6586884 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Rosenqvist Petja P Palmu Kaisa K Prajapati Ranjit Kumar RK Yamada Keith K Niemi Jarmo J Belogurov Georgiy A GA Metsä-Ketelä Mikko M Virta Pasi P
Scientific reports 20190620 1
Pseudouridimycin (PUM), a selective inhibitor of bacterial RNA polymerase has been previously detected in microbial-extracts of two strains of Streptomyces species (strain ID38640 and ID38673). Here, we isolated PUM and its deoxygenated analogue desoxy-pseudouridimycin (dPUM) from Streptomyces albus DSM 40763, previously reported to produce the metabolite strepturidin (STU). The isolated compounds were characterized by HRMS and spectroscopic techniques and they selectively inhibited transcriptio ...[more]