Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study.

ABSTRACT: OBJECTIVE:To compare the performance of three placental growth factor (PlGF)-based tests in predicting delivery within 14?days from testing in women with suspected preterm pre-eclampsia before 35?weeks' gestation. METHODS:This was a retrospective analysis of samples collected from three prospective pregnancy cohort studies. Participants were pregnant women with suspected preterm pre-eclampsia recruited in tertiary maternity units in the UK and Ireland. Samples were analyzed simultaneously according to the manufacturers' directions. The tests compared were the DELFIA Xpress PlGF 1-2-3 test, the Triage PlGF test and the Elecsys immunoassay soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio. Areas under receiver-operating characteristics curves (AUCs) were compared. The main outcome measure was detection of a difference of 0.05 in AUC between tests for delivery within 14?days of testing. RESULTS:Plasma samples from 396 women and serum samples from 244 women were assayed. In predicting delivery within 14?days secondary to suspected pre-eclampsia prior to 35?weeks' gestation, no significant differences were observed in AUCs (P =?0.795), sensitivities (P =?0.249), positive predictive values (P =?0.765) or negative predictive values (P =?0.920) between the three tests. The specificity of the Elecsys sFlt-1/PlGF ratio test was higher than that of the other two tests (P?

SUBMITTER: McCarthy FP 

PROVIDER: S-EPMC6588004 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature