Ontology highlight
ABSTRACT:
SUBMITTER: Hall ET
PROVIDER: S-EPMC6589568 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hall Eric T ET Hoesing Elizabeth E Sinkovics Endre E Verheyen Esther M EM
Molecular biology of the cell 20181212 3
Actomyosin contractility can influence the canonical Wnt signaling pathway in processes like mesoderm differentiation and tissue stiffness during tumorigenesis. We identified that increased nonmuscle myosin II activation and cellular contraction inhibited Wnt target gene transcription in developing Drosophila imaginal disks. Genetic interactions studies were used to show that this effect was due to myosin-induced accumulation of cortical F-actin resulting in clustering and accumulation of E-cadh ...[more]