Ontology highlight
ABSTRACT:
SUBMITTER: Fees CP
PROVIDER: S-EPMC6589779 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Fees Colby P CP Moore Jeffrey K JK
Molecular biology of the cell 20190123 6
How microtubules transition from depolymerization to polymerization, known as rescue, is poorly understood. Here we examine two models for rescue: 1) an "end-driven" model in which the depolymerizing end stochastically switches to a stable state; and 2) a "lattice-driven" model in which rescue sites are integrated into the microtubule before depolymerization. We test these models using a combination of computational simulations and in vitro experiments with purified tubulin. Our findings support ...[more]