Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6590987 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Li Mufeng M Wang Yao Y Banerjee Rahul R Marinelli Fabrizio F Silberberg Shai S Faraldo-Gómez José D JD Hattori Motoyuki M Swartz Kenton Jon KJ
eLife 20190624
P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets. Although several P2X3 structures are known, it is unclear how physiologically abundant Ca<sup>2+</sup>-ATP and Mg<sup>2+</sup>-ATP activate the receptor, or how divalent cations regulate channel function. We used structural, computational and functional approaches to show that a crucial acidic c ...[more]