Ontology highlight
ABSTRACT:
SUBMITTER: O'Koren EG
PROVIDER: S-EPMC6592635 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
O'Koren Emily G EG Yu Chen C Klingeborn Mikael M Wong Alicia Y W AYW Prigge Cameron L CL Mathew Rose R Kalnitsky Joan J Msallam Rasha A RA Silvin Aymeric A Kay Jeremy N JN Bowes Rickman Catherine C Arshavsky Vadim Y VY Ginhoux Florent F Merad Miriam M Saban Daniel R DR
Immunity 20190305 3
Microglia from different nervous system regions are molecularly and anatomically distinct, but whether they also have different functions is unknown. We combined lineage tracing, single-cell transcriptomics, and electrophysiology of the mouse retina and showed that adult retinal microglia shared a common developmental lineage and were long-lived but resided in two distinct niches. Microglia in these niches differed in their interleukin-34 dependency and functional contribution to visual-informat ...[more]