Ontology highlight
ABSTRACT:
SUBMITTER: Francica JR
PROVIDER: S-EPMC6597128 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Francica Joseph R JR Laga Richard R Lynn Geoffrey M GM Mužíková Gabriela G Androvič Ladislav L Aussedat Baptiste B Walkowicz William E WE Padhan Kartika K Ramirez-Valdez Ramiro Andrei RA Parks Robert R Schmidt Stephen D SD Flynn Barbara J BJ Tsybovsky Yaroslav Y Stewart-Jones Guillaume B E GBE Saunders Kevin O KO Baharom Faezzah F Petrovas Constantinos C Haynes Barton F BF Seder Robert A RA
PLoS biology 20190617 6
Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have designed synthetic "star" nanoparticles based on biocompatible N-[(2-hydroxypropyl)methacrylamide] (HPMA)-based polymer arms extending from a poly(amidoamine) (PAMAM) dendrimer core. In mice, these star ...[more]