Ontology highlight
ABSTRACT:
SUBMITTER: Cottrell CA
PROVIDER: S-EPMC7485981 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Cottrell Christopher A CA van Schooten Jelle J Bowman Charles A CA Yuan Meng M Oyen David D Shin Mia M Morpurgo Robert R van der Woude Patricia P van Breemen Mariëlle M Torres Jonathan L JL Patel Raj R Gross Justin J Sewall Leigh M LM Copps Jeffrey J Ozorowski Gabriel G Nogal Bartek B Sok Devin D Rakasz Eva G EG Labranche Celia C Vigdorovich Vladimir V Christley Scott S Carnathan Diane G DG Sather D Noah DN Montefiori David D Silvestri Guido G Burton Dennis R DR Moore John P JP Wilson Ian A IA Sanders Rogier W RW Ward Andrew B AB van Gils Marit J MJ
PLoS pathogens 20200831 8
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody ...[more]