Ontology highlight
ABSTRACT:
SUBMITTER: Kim JH
PROVIDER: S-EPMC6599567 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kim Ji Hun JH Rege Mayuri M Valeri Jacqueline J Dunagin Margaret C MC Metzger Aryeh A Titus Katelyn R KR Gilgenast Thomas G TG Gong Wanfeng W Beagan Jonathan A JA Raj Arjun A Phillips-Cremins Jennifer E JE
Nature methods 20190624 7
Mammalian genomes are folded into tens of thousands of long-range looping interactions. The cause-and-effect relationship between looping and genome function is poorly understood, and the extent to which loops are dynamic on short time scales remains an unanswered question. Here, we engineer a new class of synthetic architectural proteins for directed rearrangement of the three-dimensional genome using blue light. We target our light-activated-dynamic-looping (LADL) system to two genomic anchors ...[more]