Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.
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ABSTRACT:
SUBMITTER: Lieberman OJ
PROVIDER: S-EPMC6602586 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.
Lieberman Ori J OJ McGuirt Avery F AF Mosharov Eugene V EV Pigulevskiy Irena I Hobson Benjamin D BD Choi Sejoon S Frier Micah D MD Santini Emanuela E Borgkvist Anders A Sulzer David D
Neuron 20180726 3
Neural circuits are formed and refined during childhood, including via critical changes in neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We found that dopamine neurotransmission increases from the first to the third postnatal week in mice and precedes the reduction in spiny projection neuron (SPN) intrinsic excitability during the fourth postnatal week. In mice developmentally deficient for striatal dopamine, direct pathway D1-SPNs failed to underg ...[more]
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