Ontology highlight
ABSTRACT:
SUBMITTER: Franco A
PROVIDER: S-EPMC6602930 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Franco Aitor A Arranz Rocío R Fernández-Rivero Noelia N Velázquez-Campoy Adrián A Martín-Benito Jaime J Segura Joan J Prado Adelina A Valpuesta José M JM Muga Arturo A
Scientific reports 20190701 1
Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could bind sequentially the histone components to assemble an octamer-like particle, and crosslinked octamers with high affinity. The three-dimensional reconstruction of the NP/octamer complex generated by single-particle cryoelectron microscopy, revealed that several intrinsically ...[more]