Ontology highlight
ABSTRACT:
SUBMITTER: Sody S
PROVIDER: S-EPMC6603174 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sody Simon S Uddin Mohib M Grüneboom Anika A Görgens André A Giebel Bernd B Gunzer Matthias M Brandau Sven S
Frontiers in immunology 20190625
Across a majority of cancer types tumor-associated neutrophils (TAN) are linked with poor prognosis. However, the underlying mechanisms, especially the intratumoral behavior of TAN, are largely unknown. Using intravital multiphoton imaging on a mouse model with neutrophil-specific fluorescence, we measured the migration of TAN in distinct compartments of solid tumor cell lesions <i>in vivo</i>. By longitudinally quantifying the infiltration and persistence of TAN into growing tumors in the same ...[more]