Ontology highlight
ABSTRACT:
SUBMITTER: Corre J
PROVIDER: S-EPMC6603429 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Corre Jill J Cleynen Alice A Robiou du Pont Sébastien S Buisson Laure L Bolli Niccolo N Attal Michel M Munshi Nikhil N Avet-Loiseau Hervé H
Leukemia 20180612 12
Clonal evolution drives tumor progression, chemoresistance and relapse in cancer. Little is known about clonal selection induced by therapeutic pressure in multiple myeloma. To address this issue, we performed large targeted sequencing of bone marrow plasma cells in 43 multiple myeloma patients at diagnosis and at relapse from exactly the same intensive treatment. The most frequently mutated genes at diagnosis were KRAS (35%), NRAS (28%), DIS3 (16%), BRAF, and LRP1B (12% each). At relapse, the m ...[more]