Ontology highlight
ABSTRACT:
SUBMITTER: Lu CJ
PROVIDER: S-EPMC6604604 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lu Chong-Jian CJ Fan Xiao-Ying XY Guo Yue-Feng YF Cheng Zhen-Chao ZC Dong Ji J Chen Jin-Zi JZ Li Lian-Yan LY Wang Mei-Wen MW Wu Ze-Kai ZK Wang Fei F Tong Xiang-Jun XJ Luo Ling-Fei LF Tang Fu-Chou FC Zhu Zuo-Yan ZY Zhang Bo B
Journal of molecular cell biology 20190601 6
Pancreatic endocrine islets are vital for glucose homeostasis. However, the islet developmental trajectory and its regulatory network are not well understood. To define the features of these specification and differentiation processes, we isolated individual islet cells from TgBAC(neurod1:EGFP) transgenic zebrafish and analyzed islet developmental dynamics across four different embryonic stages using a single-cell RNA-seq strategy. We identified proliferative endocrine progenitors, which could b ...[more]