Ontology highlight
ABSTRACT:
SUBMITTER: Seo YD
PROVIDER: S-EPMC6606359 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Seo Yongwoo David YD Jiang Xiuyun X Sullivan Kevin M KM Jalikis Florencia G FG Smythe Kimberly S KS Abbasi Arezou A Vignali Marissa M Park James O JO Daniel Sara K SK Pollack Seth M SM Kim Teresa S TS Yeung Raymond R Crispe Ian Nicholas IN Pierce Robert H RH Robins Harlan H Pillarisetty Venu G VG
Clinical cancer research : an official journal of the American Association for Cancer Research 20190402 13
<h4>Purpose</h4>Pancreatic ductal adenocarcinoma (PDA) is rarely cured, and single-agent immune checkpoint inhibition has not demonstrated clinical benefit despite the presence of large numbers of CD8<sup>+</sup> T cells. We hypothesized that tumor-infiltrating CD8<sup>+</sup> T cells harbor latent antitumor activity that can be reactivated using combination immunotherapy.<h4>Experimental design</h4>Preserved human PDA specimens were analyzed using multiplex IHC (mIHC) and T-cell receptor (TCR) ...[more]