Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu K
PROVIDER: S-EPMC6606709 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Shimizu Kanako K Yamasaki Satoru S Sakurai Maki M Yumoto Noriko N Ikeda Mariko M Mishima-Tsumagari Chiemi C Kukimoto-Niino Mutsuko M Watanabe Takashi T Kawamura Masami M Shirouzu Mikako M Fujii Shin-Ichiro SI
Frontiers in immunology 20190626
Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of perforin, however, its effect on the dendritic cell (DC) is unknown. In the current study, we showed that recombinant GzmA induced the phenotypic maturation of plasmacytoid DCs (pDCs) and conventional DCs (cDCs), but not their apoptosis. Particularl ...[more]