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Enantioselective Coupling of Dienes and Phosphine Oxides.

ABSTRACT: We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes.

SUBMITTER: Nie SZ 

PROVIDER: S-EPMC6607437 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Enantioselective Coupling of Dienes and Phosphine Oxides.

Nie Shao-Zhen SZ   Davison Ryan T RT   Dong Vy M VM  

Journal of the American Chemical Society 20181119 48

We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes. ...[more]

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