Ontology highlight
ABSTRACT:
SUBMITTER: Savchenko E
PROVIDER: S-EPMC6610107 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Savchenko Ekaterina E Teku Gabriel N GN Boza-Serrano Antonio A Russ Kaspar K Berns Manon M Deierborg Tomas T Lamas Nuno J NJ Wichterle Hynek H Rothstein Jeffrey J Henderson Christopher E CE Vihinen Mauno M Roybon Laurent L
Scientific reports 20190703 1
The glutamate transporter 1 (GLT1) is upregulated during astrocyte development and maturation in vivo and is vital for astrocyte function. Yet it is expressed at low levels by most cultured astrocytes. We previously showed that maturation of human and mouse stem cell-derived astrocytes - including functional glutamate uptake - could be enhanced by fibroblast growth factor (FGF)1 or FGF2. Here, we examined the specificity and mechanism of action of FGF2 and other FGF family members, as well as ne ...[more]