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Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

ABSTRACT: Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

SUBMITTER: Smallwood PM 

PROVIDER: S-EPMC38518 | biostudies-other | 1996 Sep

REPOSITORIES: biostudies-other

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Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Smallwood P M PM   Munoz-Sanjuan I I   Tong P P   Macke J P JP   Hendry S H SH   Gilbert D J DJ   Copeland N G NG   Jenkins N A NA   Nathans J J  

Proceedings of the National Academy of Sciences of the United States of America 19960901 18

Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 (basic FGF), the FHFs lack a classical signal sequence and c  ...[more]

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