Dataset Information

Is ¹H-MR spectroscopy useful as a diagnostic aid in MSA-C?

ABSTRACT:

Background

Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disease with a cerebellar subtype where ataxic symptoms predominate (MSA-C) associated with autonomic dysfunction and a grave prognosis. The purpose of this analysis was to identify if cerebellar volumetry and MR spectroscopy obtained as part of routine clinical work up of patients with sporadic ataxia differentiates patients with multiple system atrophy- cerebellar type (MSA-C) from those with sporadic adult-onset ataxia of unknown etiology (SAOA) who's condition follows a more benign course.

Methods

Retrospective comparison was undertaken of 20 clinically probable or possible MSA-C patients, 20 age and sex matched patients with SAOA and 20 healthy control subjects. Single voxel ¹H-MR spectroscopy of the cerebellar hemisphere and vermis and volumetric analysis of the cerebellum and brainstem were undertaken on baseline scans, comparing all groups.

Results

There was significant reduction in NAA/Cr levels in patients with MSA-C when compared to those with ISA (p?=?0.005) and healthy controls (p?p?p?ConclusionThis paper demonstrates that at presentation, MSA-C patients have a significant reduction of NAA/Cr in the cerebellum and significant decrease in brainstem volume when compared to SAOA and healthy controls. This is the first study to sucessfully show clinical utility of MR spectroscopy of the cerebellum for differentiating MSA-C from patients with SAOA.

SUBMITTER: Kadodwala VH

PROVIDER: S-EPMC6612153 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Is <sup>1</sup>H-MR spectroscopy useful as a diagnostic aid in MSA-C?

Kadodwala Viren H VH Hadjivassiliou Marios M Currie Stuart S Skipper Nicholas N Hoggard Nigel N

Cerebellum & ataxias 20190705

<h4>Background</h4>Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disease with a cerebellar subtype where ataxic symptoms predominate (MSA-C) associated with autonomic dysfunction and a grave prognosis. The purpose of this analysis was to identify if cerebellar volumetry and MR spectroscopy obtained as part of routine clinical work up of patients with sporadic ataxia differentiates patients with multiple system atrophy- cerebellar type (MSA-C) from those with sporadic ...[more]

PMID: 31321064

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Is ¹H-MR spectroscopy useful as a diagnostic aid in MSA-C?

Background

Methods

Results

Publications

Is <sup>1</sup>H-MR spectroscopy useful as a diagnostic aid in MSA-C?

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Dataset Information

Is 1H-MR spectroscopy useful as a diagnostic aid in MSA-C?

Background

Methods

Results

Publications

Is <sup>1</sup>H-MR spectroscopy useful as a diagnostic aid in MSA-C?

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Is ¹H-MR spectroscopy useful as a diagnostic aid in MSA-C?