Ontology highlight
ABSTRACT:
SUBMITTER: Batista FA
PROVIDER: S-EPMC6612543 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Batista Fernando A FA Bosch Soraya S SS Butzloff Sabine S Lunev Sergey S Meissner Kamila A KA Linzke Marleen M Romero Atilio R AR Wang Chao C Müller Ingrid B IB Dömling Alexander S S ASS Groves Matthew R MR Wrenger Carsten C
MicrobiologyOpen 20190228 7
The appearance of multi-drug resistant strains of malaria poses a major challenge to human health and validated drug targets are urgently required. To define a protein's function in vivo and thereby validate it as a drug target, highly specific tools are required that modify protein function with minimal cross-reactivity. While modern genetic approaches often offer the desired level of target specificity, applying these techniques is frequently challenging-particularly in the most dangerous mala ...[more]