Ontology highlight
ABSTRACT:
SUBMITTER: Qin H
PROVIDER: S-EPMC6612629 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Qin Haiying H Edwards Justin P JP Zaritskaya Liubov L Gupta Ankit A Mu C Jenny CJ Fry Terry J TJ Hilbert David M DM LaFleur David W DW
Molecular therapy : the journal of the American Society of Gene Therapy 20190417 7
Chimeric antigen receptor (CAR) T cell therapies have demonstrated impressive initial response rates in hematologic malignancies. However, relapse rates are significant, and robust efficacies in other indications, such as solid tumors, will likely require novel therapeutic strategies and CAR designs. To that end, we sought to develop simple, highly selective targeting domains (D domains) that could be incorporated into complex, multifunctional therapeutics. Herein, we describe the identification ...[more]