Ontology highlight
ABSTRACT:
SUBMITTER: Perkins JC
PROVIDER: S-EPMC6613383 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20171127 24
The convergent synthesis of bicyclo[2.2.2]diazaoctane structures using an intermolecular Diels-Alder cycloaddition between a pyrazinone and commercially available fumarate or maleate precursors is reported. High reactivity and stereoselection is observed with both dienophile substrates. Structure validation was achieved by conversion of cycloadducts into known [2.2.2]diazabicyclic compounds or into crystalline derivatives suitable for X-ray analysis. The cycloadduct derived from reaction of pyra ...[more]