Ontology highlight
ABSTRACT:
SUBMITTER: Selvaraju K
PROVIDER: S-EPMC6614553 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Selvaraju Karthik K Mofers Arjan A Pellegrini Paola P Salomonsson Johannes J Ahlner Alexandra A Morad Vivian V Hillert Ellin-Kristina EK Espinosa Belen B Arnér Elias S J ESJ Jensen Lasse L Malmström Jonas J Turkina Maria V MV D'Arcy Padraig P Walters Michael A MA Sunnerhagen Maria M Linder Stig S
Scientific reports 20190708 1
A large number of natural products have been advocated as anticancer agents. Many of these compounds contain functional groups characterized by chemical reactivity. It is not clear whether distinct mechanisms of action can be attributed to such compounds. We used a chemical library screening approach to demonstrate that a substantial fraction (~20%) of cytotoxic synthetic compounds containing Michael acceptor groups inhibit proteasome substrate processing and induce a cellular response character ...[more]