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Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.

ABSTRACT: PURPOSE:Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated. METHODS:Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, overweight/obesity weight, and physical inactivity and overall survival (OS) as well as progression-free survival (PFS) among women diagnosed with invasive epithelial ovarian carcinoma (n?=?7,022). Using age- and stage-adjusted Cox proportional hazards regression models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) associated with joint exposure to these factors. RESULTS:Combined exposure to current smoking, overweight/obesity, and physical inactivity prior to diagnosis was associated with a significantly increased risk of mortality compared to women who never smoked, had normal body mass index (BMI), and were physically active (HR?=?1.37; 95% CI 1.10-1.70). The association for a joint exposure to these factors exceeded that of each exposure individually. In fact, exposure to both current smoking and overweight/obesity, and current smoking and physical inactivity was also associated with increased risk of death (HR?=?1.28; 95% CI 1.08-1.52, and HR?=?1.26; 95% CI 1.04-1.54, respectively). The associations were of a similar magnitude when former smoking was assessed in combination with the other exposures and when excessive weight was limited to obesity only. No significant associations were observed between joint exposure to any of these factors and PFS. CONCLUSIONS:Joint exposure to smoking, excessive weight, and physical inactivity may negatively impact survival of ovarian cancer patients. These results suggest the importance of examining the combined effect of lifestyle factors on ovarian cancer patients' survival.

SUBMITTER: Minlikeeva AN

PROVIDER: S-EPMC6614876 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.

Minlikeeva Albina N AN Cannioto Rikki R Jensen Allan A Kjaer Susanne K SK Jordan Susan J SJ Diergaarde Brenda B Szender J Brian JB Odunsi Kunle K Almohanna Hani H Mayor Paul P Starbuck Kirsten K Zsiros Emese E Bandera Elisa V EV Cramer Daniel W DW Doherty Jennifer A JA DeFazio Anna A Edwards Robert R Goode Ellen L EL Goodman Marc T MT Høgdall Estrid E Matsuo Keitary K Mizuno Mika M Nagle Christina M CM Ness Roberta B RB Paddock Lisa E LE Pearce Celeste L CL Risch Harvey A HA Rossing Mary Anne MA Terry Kathryn L KL Wu Anna H AH Modugno Francesmary F Webb Penelope M PM Moysich Kirsten B KB

Cancer causes & control : CCC 20190323 5

<h4>Purpose</h4>Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated.<h4>Methods</h4>Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, overweight/obesity weight, and physical inactivity and overall su ...[more]

PMID: 30905014

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Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.

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Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium.

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