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Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions.

SUBMITTER: Lee SA 

PROVIDER: S-EPMC6618585 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Global Investigations of <i>Fusobacterium nucleatum</i> in Human Colorectal Cancer.

Lee Seul A SA   Liu Fang F   Riordan Stephen M SM   Lee Cheok S CS   Zhang Li L  

Frontiers in oncology 20190703

Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of <i>Fusobacterium nucleatum</i> in the development of CRC. In this article, we review studies from different geographical regions examining the association between <i>F. nucleatum</i> and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of <i>F. nucleatum</i> in CRC and sugges  ...[more]

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