Ontology highlight
ABSTRACT:
SUBMITTER: Mangano K
PROVIDER: S-EPMC6628530 | biostudies-literature | 2019 Jan-Dec
REPOSITORIES: biostudies-literature
Mangano Katia K Lanteri Raffaele R Basile Maria Sofia MS Bellavia Noemi N Latino Rosalia R Messina Domenico D Fagone Paolo P Colletti Giuseppe G Nania Riccardo R Caltabiano Rosario R Di Marco Roberto R Di Cataldo Antonio A
International journal of immunopathology and pharmacology 20190101
Hepatic ischemia/reperfusion injury (IRI) is a clinical condition that may lead to cellular injury and organ dysfunction that can be observed in different conditions, such as trauma, shock, liver resection, and transplantation. Moderate levels of nitric oxide (NO) produced by the endothelial isoform of the NO synthase protect against liver IRI. GIT-27NO is a NO-derivative of the toll-like receptor 4 antagonist VGX-1027 that has been shown to possess both antineoplastic and immunomodulatory prope ...[more]