Ontology highlight
ABSTRACT:
SUBMITTER: Bangaru S
PROVIDER: S-EPMC6629437 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Bangaru Sandhya S Lang Shanshan S Schotsaert Michael M Vanderven Hillary A HA Zhu Xueyong X Kose Nurgun N Bombardi Robin R Finn Jessica A JA Kent Stephen J SJ Gilchuk Pavlo P Gilchuk Iuliia I Turner Hannah L HL García-Sastre Adolfo A Li Sheng S Ward Andrew B AB Wilson Ian A IA Crowe James E JE
Cell 20190501 5
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epitope in the HA trimer interface, suggesting previously unrecognized dynamic features of the trimeric HA protein. The critical HA residues recognized by FluA-20 remain conserved across most subtypes of i ...[more]