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A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging.

ABSTRACT: Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg²⁺ ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (PMH) was facilely synthesized by incorporating phenylimidazole fluorophore and 3-methyl-2- benzothiazolinone hydrazone hydrochloride monohydrate. The PMH probe exhibited a ratiometric response for Hg²⁺ ions with fluorescence intensity increasing at 520 nm and decreasing at 445 nm simultaneously. The PMH probe interacted with Hg²⁺ ions in seconds with high optical stability and showed good selectivity over other metal ions. In addition, the probe has excellent biocompatibility and imaging performance in cells and zebrafish.

SUBMITTER: Gao Q

PROVIDER: S-EPMC6630643 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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A Novel Ratiometric Fluorescent Probe for Mercury (II) ions and Application in Bio-imaging.

Gao Qianmiao Q Jiao Yang Y He Cheng C Duan Chunying C

Molecules (Basel, Switzerland) 20190618 12

Since the accumulation of mercury (II) ions in the environment and ecosystem causes serious problems to environment and disease, the recognition of Hg2+ ions and its bio-imaging is of high importance. In sight of the advantages of fluorescence probes, a new probe (PMH) was facilely synthesized by incorporating phenylimidazole fluorophore and 3-methyl-2- benzothiazolinone hydrazone hydrochloride monohydrate. The PMH probe exhibited a ratiometric response for Hg2+</su ...[more]

PMID: 31216754

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