Ontology highlight
ABSTRACT:
SUBMITTER: Mahgoub MY
PROVIDER: S-EPMC6630738 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190621 12
A new series of thiazolo[3,2-<i>a</i>]pyrimidine bromide salt derivatives <b>7a</b>-<b>d</b> were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, which confirmed a regioselective 5<i>H</i> cyclization of the dihydropyrimidinethiones. All target compounds were evaluated in vitro as human acetylcholinesterase (<i>h</i>AChE) inhibitors via an Ellman-base ...[more]