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Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents.

ABSTRACT: Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

SUBMITTER: Fares M

PROVIDER: S-EPMC9049071 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents.

Fares Mohamed M McCosker Patrick M PM Alsherbiny Muhammad A MA Willis Anthony C AC Clark Timothy T Neyts Johan J Jochmans Dirk D Keller Paul A PA

RSC advances 20200131 9

Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present. ...[more]

PMID: 35498334

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