Ontology highlight
ABSTRACT:
SUBMITTER: Afonso PV
PROVIDER: S-EPMC6638983 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Afonso Philippe V PV Fagrouch Zahra Z Deijs Martin M Niphuis Henk H Bogers Willy W Gessain Antoine A van der Hoek Lia L Verschoor Ernst J EJ
PLoS neglected tropical diseases 20190708 7
<h4>Background</h4>Primate T-lymphotropic viruses type 1 (PTLV-1) are complex retroviruses infecting both human (HTLV-1) and simian (STLV-1) hosts. They share common epidemiological, clinical and molecular features. In addition to the canonical gag, pol, env retroviral genes, PTLV-1 purportedly encodes regulatory (i.e. Tax, Rex, and HBZ) and accessory proteins (i.e. P12/8, P13, P30). The latter have been found essential for viral persistence in vivo.<h4>Methodology/principal findings</h4>We have ...[more]