Ontology highlight
ABSTRACT:
SUBMITTER: Ahdash Z
PROVIDER: S-EPMC6639072 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ahdash Zainab Z Pyle Euan E Allen William John WJ Corey Robin A RA Collinson Ian I Politis Argyris A
eLife 20190710
The bacterial Sec translocon is a multi-protein complex responsible for translocating diverse proteins across the plasma membrane. For post-translational protein translocation, the Sec-channel - SecYEG - associates with the motor protein SecA to mediate the ATP-dependent transport of pre-proteins across the membrane. Previously, a diffusional-based Brownian ratchet mechanism for protein secretion has been proposed; the structural dynamics required to facilitate this mechanism remain unknown. Her ...[more]