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Songbird Ventral Pallidum Sends Diverse Performance Error Signals to Dopaminergic Midbrain.

ABSTRACT: Motor skills improve with practice, requiring outcomes to be evaluated against ever-changing performance benchmarks, yet it remains unclear how performance error signals are computed. Here, we show that the songbird ventral pallidum (VP) is required for song learning and sends diverse song timing and performance error signals to the ventral tegmental area (VTA). Viral tracing revealed inputs to VP from auditory and vocal motor thalamus, auditory and vocal motor cortex, and VTA. Our findings show that VP circuits, commonly associated with hedonic functions, signal performance error during motor sequence learning.

SUBMITTER: Chen R

PROVIDER: S-EPMC6639146 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Songbird Ventral Pallidum Sends Diverse Performance Error Signals to Dopaminergic Midbrain.

Chen Ruidong R Puzerey Pavel A PA Roeser Andrea C AC Riccelli Tori E TE Podury Archana A Maher Kamal K Farhang Alexander R AR Goldberg Jesse H JH

Neuron 20190529 2

Motor skills improve with practice, requiring outcomes to be evaluated against ever-changing performance benchmarks, yet it remains unclear how performance error signals are computed. Here, we show that the songbird ventral pallidum (VP) is required for song learning and sends diverse song timing and performance error signals to the ventral tegmental area (VTA). Viral tracing revealed inputs to VP from auditory and vocal motor thalamus, auditory and vocal motor cortex, and VTA. Our findings show ...[more]

PMID: 31153647

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