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Ultrafast Self-Healable Interfaces in Polyurethane Nanocomposites Designed Using Diels-Alder "Click" as an Efficient Microwave Absorber.

ABSTRACT: In the recent times, multifunctional materials have attracted immense interest. Self-healing polymers are in great demand in almost every coating application. With an increase in electromagnetic (EM) pollution, curbing the same has become an urgent necessity. Lightweight coatings and conducting polymeric materials are being highly researched upon in this regard, and combining these properties with self-healing systems would open new avenues in EM interference (EMI) shielding (specifically in the microwave frequency domain) applications. In the current study, a novel approach toward the development of microwave shielding materials capable of self-healing through microwave heating has been attempted. A covalently cross-linked material was developed using Diels-Alder (DA) chemistry, which shows self-healing properties when stimulated by heating. Herein, reduced graphene oxide grafted with magnetite nanoparticles (rGO/Fe₃O₄) was covalently cross-linked to thermoplastic polyurethane using DA chemistry. The addition of multiwalled carbon nanotubes into these nanocomposites led to exceptional EM wave shielding and self-healing properties through a synergistic effect. The synergism led to exceptional EMI shielding of -36 dB, primarily through absorption in the microwave region of the EM spectrum. When used in the form of thin coatings of about 1 mm in thickness, the shielding value reached -28 dB, manifesting in more than 99% attenuation of EM waves through absorption. The material was also found to be capable of healing scratches or cuts through microwave irradiation.

SUBMITTER: Menon AV

PROVIDER: S-EPMC6641351 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Ultrafast Self-Healable Interfaces in Polyurethane Nanocomposites Designed Using Diels-Alder "Click" as an Efficient Microwave Absorber.

Menon Aishwarya V AV Madras Giridhar G Bose Suryasarathi S

ACS omega 20180126 1

In the recent times, multifunctional materials have attracted immense interest. Self-healing polymers are in great demand in almost every coating application. With an increase in electromagnetic (EM) pollution, curbing the same has become an urgent necessity. Lightweight coatings and conducting polymeric materials are being highly researched upon in this regard, and combining these properties with self-healing systems would open new avenues in EM interference (EMI) shielding (specifically in the ...[more]

PMID: 31457956

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Project description:UnlabelledThe specificity of antibodies have made immunoconjugates promising vectors for the delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives necessitate the use of radioisotopes with long physical half-lives, a combination that leads to high radiation doses to patients. Therefore, the development of targeting modalities that harness the advantages of antibodies without their pharmacokinetic limitations is desirable. To this end, we report the development of a methodology for pretargeted PET imaging based on the bioorthogonal Diels-Alder click reaction between tetrazine and transcyclooctene.MethodsA proof-of-concept system based on the A33 antibody, SW1222 colorectal cancer cells, and (64)Cu was used. The huA33 antibody was covalently modified with transcyclooctene, and a NOTA-modified tetrazine was synthesized and radiolabeled with (64)Cu. Pretargeted in vivo biodistribution and PET imaging experiments were performed with athymic nude mice bearing A33 antigen-expressing, SW1222 colorectal cancer xenografts.ResultsThe huA33 antibody was modified with transcyclooctene to produce a conjugate with high immunoreactivity, and the (64)Cu-NOTA-labeled tetrazine ligand was synthesized with greater than 99% purity and a specific activity of 9-10 MBq/μg. For in vivo experiments, mice bearing SW1222 xenografts were injected with transcyclooctene-modified A33; after allowing 24 h for accumulation of the antibody in the tumor, the mice were injected with (64)Cu-NOTA-labeled tetrazine for PET imaging and biodistribution experiments. At 12 h after injection, the retention of uptake in the tumor (4.1 ± 0.3 percent injected dose per gram), coupled with the fecal excretion of excess radioligand, produced images with high tumor-to-background ratios. PET imaging and biodistribution experiments performed using A33 directly labeled with either (64)Cu or (89)Zr revealed that although absolute tumor uptake was higher with the directly radiolabeled antibodies, the pretargeted system yielded comparable images and tumor-to-muscle ratios at 12 and 24 h after injection. Further, dosimetry calculations revealed that the (64)Cu pretargeting system resulted in only a fraction of the absorbed background dose of A33 directly labeled with (89)Zr (0.0124 mSv/MBq vs. 0.4162 mSv/MBq, respectively).ConclusionThe high quality of the images produced by this pretargeting approach, combined with the ability of the methodology to dramatically reduce nontarget radiation doses to patients, marks this system as a strong candidate for clinical translation.

Dataset Information

Ultrafast Self-Healable Interfaces in Polyurethane Nanocomposites Designed Using Diels-Alder "Click" as an Efficient Microwave Absorber.

Publications

Ultrafast Self-Healable Interfaces in Polyurethane Nanocomposites Designed Using Diels-Alder "Click" as an Efficient Microwave Absorber.

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