Ontology highlight
ABSTRACT:
SUBMITTER: Mutter AC
PROVIDER: S-EPMC6642340 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mutter Andrew C AC Tyryshkin Alexei M AM Campbell Ian J IJ Poudel Saroj S Bennett George N GN Silberg Jonathan J JJ Nanda Vikas V Falkowski Paul G PG
Proceedings of the National Academy of Sciences of the United States of America 20190701 29
A symmetric origin for bacterial ferredoxins was first proposed over 50 y ago, yet, to date, no functional symmetric molecule has been constructed. It is hypothesized that extant proteins have drifted from their symmetric roots via gene duplication followed by mutations. Phylogenetic analyses of extant ferredoxins support the independent evolution of N- and C-terminal sequences, thereby allowing consensus-based design of symmetric 4Fe-4S molecules. All designs bind two [4Fe-4S] clusters and exhi ...[more]