Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.
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ABSTRACT:
SUBMITTER: Peron F
PROVIDER: S-EPMC6643515 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.
Péron Florent F Riché Stéphanie S Lesur Brigitte B Hibert Marcel M Breton Philippe P Fourquez Jean-Marie JM Girard Nicolas N Bonnet Dominique D
ACS omega 20181109 11
Herein, we report a convenient synthesis of unprecedented aza-diketopiperazines (aza-DKPs). The strategy is based on selective diversification of bicyclic aza-DKP scaffolds by click reaction, N-acylation, and/or N-alkylation. These scaffolds containing either azido or amino groups were obtained by a key Rh(I)-catalyzed hydroformylative cyclohydrocarbonylation reaction of allyl-substituted aza-DKP. The methodology is readily amenable to the parallel synthesis of original aza-DKPs to enlarge the c ...[more]
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