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On/Off Fluorescent Chemosensor for Selective Detection of Divalent Iron and Copper Ions: Molecular Logic Operation and Protein Binding.

ABSTRACT: Here, naphthalene diamine-based ?-diketone derivative (compound LH) was successfully used as a dual signaling probe for divalent cations, Fe²⁺ and Cu²⁺ ions, in bimodal methods (colorimetric and fluorometric). It showed fluorescent enhancement for Fe²⁺ ion by photoinduced electron transfer mechanism and fluorescence quenching for Cu²⁺ ion by charge-transfer process. Binding stoichiometry for [LH-(Fe²⁺)₂] and [LH-(Cu²⁺)₂] was found to be 1:2 by Job's plot method and, the binding constants were calculated as 1.6638 × 10¹⁰ and 9.22929 × 10⁸ M^-1, respectively. Compound LH exhibited OR and XOR logic gate behavior with H⁺, Fe²⁺, and Cu²⁺ as inputs. Further, the compound LH and bovine serum albumin binding interaction showed quenching of fluorescence by Förster resonance energy-transfer mechanism.

SUBMITTER: Tamil Selvan G

PROVIDER: S-EPMC6644644 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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On/Off Fluorescent Chemosensor for Selective Detection of Divalent Iron and Copper Ions: Molecular Logic Operation and Protein Binding.

Tamil Selvan G G Varadaraju Chitra C Tamil Selvan R R Enoch Israel V M V IVMV Mosae Selvakumar P P

ACS omega 20180718 7

Here, naphthalene diamine-based β-diketone derivative (compound LH) was successfully used as a dual signaling probe for divalent cations, Fe2+ and Cu2+ ions, in bimodal methods (colorimetric and fluorometric). It showed fluorescent enhancement for Fe2+ ion by photoinduced electron transfer mechanism and fluorescence quenching for Cu2+ ion by charge-transfer process. Binding stoichiometry for [LH-(Fe2+)2] and [LH-(Cu2+)< ...[more]

PMID: 31458937

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