Ontology highlight
ABSTRACT:
SUBMITTER: Puneeth Kumar DR
PROVIDER: S-EPMC9945854 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Puneeth Kumar DRGKoppalu R DR Reja Rahi M RM Senapati Dillip K DK Singh Manjeet M Nalawade Sachin A SA George Gijo G Kaul Grace G Akhir Abdul A Chopra Sidharth S Raghothama Srinivasarao S Gopi Hosahudya N HN
RSC medicinal chemistry 20221210 2
Directing Aβ<sub>42</sub> to adopt a conformation that is free from aggregation and cell toxicity is an attractive and viable strategy to design therapeutics for Alzheimer's disease. Over the years, extensive efforts have been made to disrupt the aggregation of Aβ<sub>42</sub> using various types of inhibitors but with limited success. Herein, we report the inhibition of aggregation of Aβ<sub>42</sub> and disintegration of matured fibrils of Aβ<sub>42</sub> into smaller assemblies by a 15-mer ca ...[more]