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Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity.

ABSTRACT: To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake.

SUBMITTER: Gunawan C

PROVIDER: S-EPMC6648134 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity.

Gunawan Cindy C Lord Megan S MS Lovell Emma E Wong Roong Jien RJ Jung Moon Sun MS Oscar Diana D Mann Riti R Amal Rose R

ACS omega 20190530 5

To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to als ...[more]

PMID: 31460038

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