Dataset Information

Recyclable Au/SiO₂-Shell/Fe₃O₄-Core Catalyst for the Reduction of Nitro Aromatic Compounds in Aqueous Solution.

ABSTRACT: Highly stable gold nanoparticles immobilized on the surface of amine-functionalized nanocomposite microspheres possessing a magnetite (Fe₃O₄) nanoparticle core and a silica (SiO₂) shell (Au/SiO₂-shell/Fe₃O₄-core) were prepared. These gold nanocomposite catalysts were tested for 4-nitrophenol (4-NP) and 2-nitroaniline (2-NA) reduction in aqueous solution in the temperature range 293-323 K and in the presence of aqueous NaBH₄ reducing agent. The magnetically recyclable gold catalyst showed high stability (∼3 months), efficient recyclability (up to 10 cycles), and high activity (∼100% conversion within 225 s, ∼700 ppm 4-NP or 2-NA). The pseudo-first-order apparent reaction rate constants (k) of 4-NP and 2-NA reduction were 7.5 × 10^-3 and 4.1 × 10^-3 s^-1, respectively, and with an apparent catalytic activity of 4.48 × 10^-8 kmol/(m³ s).

SUBMITTER: Bhaduri K

PROVIDER: S-EPMC6649094 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:BackgroundUnderstanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.MethodsIn this study, the biodistribution and the size-dependent biological effects of Fe3O4@SiO2-NH2 nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.ResultsOur findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.ConclusionThe integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.

Dataset Information

Recyclable Au/SiO₂-Shell/Fe₃O₄-Core Catalyst for the Reduction of Nitro Aromatic Compounds in Aqueous Solution.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Recyclable Au/SiO2-Shell/Fe3O4-Core Catalyst for the Reduction of Nitro Aromatic Compounds in Aqueous Solution.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Recyclable Au/SiO₂-Shell/Fe₃O₄-Core Catalyst for the Reduction of Nitro Aromatic Compounds in Aqueous Solution.