Production and in vivo PET/CT imaging of the theranostic pair 132/135La.
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ABSTRACT:
SUBMITTER: Aluicio-Sarduy E
PROVIDER: S-EPMC6650468 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Production and in vivo PET/CT imaging of the theranostic pair <sup>132/135</sup>La.
Aluicio-Sarduy Eduardo E Hernandez Reinier R Olson Aeli P AP Barnhart Todd E TE Cai Weibo W Ellison Paul A PA Engle Jonathan W JW
Scientific reports 20190723 1
The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added <sup>132/135</sup>La<sup>3+</sup> from bulk <sup>nat</sup>Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced <sup>132/135</sup>La<sup>3+</sup> has a radioc ...[more]
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