Ontology highlight
ABSTRACT:
SUBMITTER: Kozlowska E
PROVIDER: S-EPMC6656742 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kozłowska Ewa E Dymarska Monika M Kostrzewa-Susłow Edyta E Janeczko Tomasz T
Scientific reports 20190724 1
Estrone, estradiol, ethynylestradiol and estrone 3-methyl ether underwent a biotransformation process in the submerged culture of Isaria fumosorosea KCh J2. Estrone was transformed into seven metabolites, four of which were glycosylated. Estradiol was selectively glycosylated at C-3 and then transformed to D-ring lactone. Ethynylestradiol was coupled with methylglucoside and 6β-hydroxyderivative was obtained. Estrone 3-methyl ether was not transformed indicating that a free hydroxyl group at C-3 ...[more]