Ontology highlight
ABSTRACT:
SUBMITTER: Moakley D
PROVIDER: S-EPMC6658502 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Moakley Daniel D Koh Joan J Pereira Joao D JD DuBreuil Daniel M DM Devlin Anna-Claire AC Berezovski Eugene E Zhu Kevin K Wainger Brian J BJ
Scientific reports 20190725 1
Directed differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of specific neuronal subtypes that approximate the intended primary mammalian cells on both the RNA and protein levels. These cells offer unique opportunities, including insights into mechanistic understanding of the early driving events in neurodegenerative disease, replacement of degenerating cell populations, and compound identification and evaluation in the context of precision medicine. However, whet ...[more]