GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population.
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ABSTRACT:
SUBMITTER: Jia H
PROVIDER: S-EPMC6659273 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population.
Jia Huijuan H Nogawa Shun S Kawafune Kaoru K Hachiya Tsuyoshi T Takahashi Shoko S Igarashi Maki M Saito Kenji K Kato Hisanori H
BMC genetics 20190726 1
<h4>Background</h4>Studies on genetic effects of coffee consumption are scarce for Asian populations. We conducted a genome-wide association study (GWAS) of habitual coffee consumption in Japan using a self-reporting online survey.<h4>Results</h4>Candidate genetic loci associated with habitual coffee consumption were searched within a discovery cohort (N = 6,264) and confirmed in a replication cohort (N = 5,975). Two loci achieved genome-wide significance (P < 5 × 10<sup>- 8</sup>) in a meta-ana ...[more]
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