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Parahydrogen-Induced Polarization of 1-13C-Acetates and 1-13C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters.


ABSTRACT: 13C-hyperpolarized carboxylates, such as pyruvate and acetate, are emerging molecular contrast agents for MRI visualization of various diseases, including cancer. Here we present a systematic study of 1H and 13C parahydrogen-induced polarization of acetate and pyruvate esters with ethyl, propyl and allyl alcoholic moieties. It was found that allyl pyruvate is the most efficiently hyperpolarized compound from those under study, yielding 21% and 5.4% polarization of 1H and 13C nuclei, respectively, in CD3OD solutions. Allyl pyruvate and ethyl acetate were also hyperpolarized in aqueous phase using homogeneous hydrogenation with parahydrogen over water-soluble rhodium catalyst. 13C polarization of 0.82% and 2.1% was obtained for allyl pyruvate and ethyl acetate, respectively. 13C-hyperpolarized methanolic and aqueous solutions of allyl pyruvate and ethyl acetate were employed for in vitro MRI visualization, demonstrating the prospects for translation of the presented approach to biomedical in vivo studies.

SUBMITTER: Salnikov OG 

PROVIDER: S-EPMC6664436 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Parahydrogen-Induced Polarization of 1-<sup>13</sup>C-Acetates and 1-<sup>13</sup>C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters.

Salnikov Oleg G OG   Chukanov Nikita V NV   Shchepin Roman V RV   Manzanera Esteve Isaac V IV   Kovtunov Kirill V KV   Koptyug Igor V IV   Chekmenev Eduard Y EY  

The journal of physical chemistry. C, Nanomaterials and interfaces 20190419 20


<sup>13</sup>C-hyperpolarized carboxylates, such as pyruvate and acetate, are emerging molecular contrast agents for MRI visualization of various diseases, including cancer. Here we present a systematic study of <sup>1</sup>H and <sup>13</sup>C parahydrogen-induced polarization of acetate and pyruvate esters with ethyl, propyl and allyl alcoholic moieties. It was found that allyl pyruvate is the most efficiently hyperpolarized compound from those under study, yielding 21% and 5.4% polarization o  ...[more]

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