Parahydrogen-Induced Polarization of 1-¹³C-Acetates and 1-¹³C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters.

ABSTRACT: ¹³C-hyperpolarized carboxylates, such as pyruvate and acetate, are emerging molecular contrast agents for MRI visualization of various diseases, including cancer. Here we present a systematic study of ¹H and ¹³C parahydrogen-induced polarization of acetate and pyruvate esters with ethyl, propyl and allyl alcoholic moieties. It was found that allyl pyruvate is the most efficiently hyperpolarized compound from those under study, yielding 21% and 5.4% polarization of ¹H and ¹³C nuclei, respectively, in CD₃OD solutions. Allyl pyruvate and ethyl acetate were also hyperpolarized in aqueous phase using homogeneous hydrogenation with parahydrogen over water-soluble rhodium catalyst. ¹³C polarization of 0.82% and 2.1% was

SUBMITTER: Salnikov OG 

PROVIDER: S-EPMC6664436 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature