Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats.

ABSTRACT: The present study was sought to evaluate the oxidative, antioxidant status and histopathological changes by the acute chronic exposure of formaldehyde. Bronco-T a poly-herbal formulation treatment, changes the oxidative, antioxidant status and histopathology of rat lungs with antioxidant and regenerative property. In this experiment thirty adult male albino Wister rats were used for the study and subdivided in to five groups consist of 6 rats for each group. Group-I served as control and the other 4 groups such as II, III, IV and V are considered as experimental. The control and treatment rats are maintained for 21 days of experimental period. Experimental rats are exposed to 40 percent formaldehyde for 1?h treated with Bronco-T and salbutamol. In the present investigation, the formaldehyde exposed rats a series of free radical chain reactions were grimly provoked, the evaluation of antioxidant enzymes (SOD, CAT), other enzymes oxidative enzymes (G-6-PDH, SDH) and (ALT, ALAT and LDH) were measured. A clear assertive imbalance between oxidation and anti-oxidation status was critically observed, and oxidative stress was clearly exacerbated in lung tissue leading to altrations in architecture of lung histopathology. Oral gavage Bronco-T exhibits a beneficial action by bringing normal architecture in lung tissue of formaldehyde inhaled rats with antioxidant properties. Bronco-T treatment may be a suitable remedy for formalin occupational diseases.

SUBMITTER: Payani S 

PROVIDER: S-EPMC6667771 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature