Ontology highlight
ABSTRACT:
SUBMITTER: Orthmann-Murphy JL
PROVIDER: S-EPMC6673504 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Orthmann-Murphy Jennifer L JL Freidin Mona M Fischer Esther E Scherer Steven S SS Abrams Charles K CK
The Journal of neuroscience : the official journal of the Society for Neuroscience 20071201 51
Genetic diseases demonstrate that the normal function of CNS myelin depends on connexin32 (Cx32) and Cx47, gap junction (GJ) proteins expressed by oligodendrocytes. GJs couple oligodendrocytes and astrocytes (O/A channels) as well as astrocytes themselves (A/A channels). Because astrocytes express different connexins (Cx30 and Cx43), O/A channels must be heterotypic, whereas A/A channels may be homotypic or heterotypic. Using electrophysiological and immunocytochemical approaches, we found that ...[more]