Ontology highlight
ABSTRACT:
SUBMITTER: Sung YJ
PROVIDER: S-EPMC6674025 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Sung Ying-Ju YJ Wu Fang F Schacher Samuel S Ambron Richard T RT
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060601 24
The activator protein-1 (AP1) transcription complex remains active for long periods after axotomy, but its activity diminishes during target contact. This raises the possibility that the function of this complex is regulated by the synaptic connections. Using Aplysia californica, we found that crushing peripheral nerves in vivo enhanced AP1 binding in the sensory neurons that lasted for weeks and then declined as regeneration was completed. The AP1 complex in Aplysia is a c-Jun homodimer. Its ac ...[more]